Description
Research Peptide≥99% HPLC StandardShips from Canada
Overview
KPV is a synthetic tripeptide corresponding to the C-terminal three residues (lysine-proline-valine) of the hormone α-melanocyte-stimulating hormone (α-MSH). Despite its small size it retains much of the anti-inflammatory activity of the parent hormone. It is supplied as a stable lyophilized peptide.
In research it is studied mainly for anti-inflammatory signalling, notably in models of gut and mucosal inflammation, where it appears to act partly through pathways independent of the classical melanocortin receptors. It is offered strictly as a research material, and the study cited below describes preclinical findings only.
Mechanisms of interest in research
Anti-inflammatory signalling and NF-κB
KPV is studied for dampening pro-inflammatory signalling, including interference with the NF-κB pathway that drives cytokine production. This activity is examined as a mechanism for reduced inflammation in cell and animal models.
Melanocortin-receptor-independent action
Unlike the full α-MSH hormone, the effects of KPV have been observed even where melanocortin-receptor signalling is limited, suggesting it can act through receptor-independent routes — a distinctive feature of its research profile.
Mucosal and gut-inflammation models
Much of the KPV literature concerns intestinal inflammation, where it is studied for effects on mucosal immune cells and epithelial transport.
Specifications
Selected Research
The following peer-reviewed studies are provided for scientific context on this compound’s research background. They describe preclinical and in-vitro findings only and are not claims about this product.
KPV showed significant anti-inflammatory effects in two murine models of colitis that appeared at least partly independent of MC1R signalling.
Kannengiesser K, et al. Inflamm Bowel Dis. PMID: 18092346
This product is intended exclusively for in-vitro laboratory research. It is not a drug, food, dietary supplement, or cosmetic, and it is not intended for human or veterinary diagnostic, therapeutic, or recreational use.
