Description
Research Compound≥99% HPLC StandardShips from Canada
Overview
Dihexa (N-hexanoic-Tyr-Ile-(6)-aminohexanoic amide) is a small-molecule analog of angiotensin IV, engineered as a metabolically stable peptidomimetic. Chemical modifications at both ends make it resistant to the peptidases that rapidly degrade natural peptides and allow it to cross biological membranes, so despite its peptide-like origin it behaves as a stable small-molecule compound.
In research it is studied for neurotrophic effects, particularly the formation of new synaptic connections, which it appears to drive by engaging the hepatocyte growth factor (HGF) / c-Met signalling system. It is offered strictly as a research material, and the studies cited below describe preclinical findings only.
Mechanisms of interest in research
HGF / c-Met system activation
Dihexa is studied as a positive modulator of hepatocyte growth factor and its receptor c-Met. By enhancing this signalling it is associated with dendritic arborization and the formation of new synapses in neuronal models.
Synaptogenesis and cognition models
The synapse-forming activity has made dihexa a subject of cognition and neurodegeneration research, where new functional synaptic connections are examined in animal models.
Metabolic stability as a peptidomimetic
Unlike native angiotensin IV, dihexa resists peptidase degradation and penetrates tissues, properties central to its use as a research tool for probing HGF/c-Met-dependent neurotrophic effects.
Specifications
Selected Research
The following peer-reviewed studies are provided for scientific context on this compound’s research background. They describe preclinical and in-vitro findings only and are not claims about this product.
This study reports that dihexa induces dendritic arborization and synaptogenesis by activating the HGF/c-Met system, facilitating new functional synaptic connections and memory consolidation in Alzheimer-disease animal models.
Wright JW, et al. J Alzheimers Dis. PMID: 25649658
In zebrafish lateral-line cells, the HGF mimetic dihexa protected sensory hair cells against aminoglycoside toxicity through an HGF-mediated mechanism.
Uribe PM, et al. Front Cell Neurosci. PMID: 25674052
This product is intended exclusively for in-vitro laboratory research. It is not a drug, food, dietary supplement, or cosmetic, and it is not intended for human or veterinary diagnostic, therapeutic, or recreational use.
