Description
Research Peptide≥99% HPLC StandardShips from Canada
Overview
Hexarelin is a synthetic hexapeptide (His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH₂) and a potent agonist of the ghrelin / growth-hormone-secretagogue receptor (GHS-R1a), structurally related to GHRP-6. It is supplied as a stable lyophilized peptide.
In research it is studied both as a strong stimulus of growth-hormone (GH) release and, separately, for cardiovascular effects that appear independent of GH — an unusual dual interest for a secretagogue. It is offered strictly as a research material, and the studies cited below describe preclinical and clinical-pharmacology findings only.
Mechanisms of interest in research
Ghrelin / GHS-R1a receptor agonism and GH release
Hexarelin binds GHS-R1a to trigger potent GH release from the pituitary. In model systems its GH response is reproducible and can be modulated by sex-steroid status, making it a well-characterised probe of the GH axis.
CD36 binding and cardiovascular signalling
Beyond the ghrelin receptor, hexarelin also binds the scavenger receptor CD36, identified as a cardiac receptor through which it is studied for cardioprotective effects independent of GH release. This second receptor is a distinctive focus of hexarelin research.
Specifications
Selected Research
The following peer-reviewed studies are provided for scientific context on this compound’s research background. They describe preclinical and in-vitro findings only and are not claims about this product.
In prepubertal short-statured children, hexarelin produced reproducible GH secretion, and priming with testosterone or ethinyl estradiol significantly enhanced the GH response while oxandrolone did not.
Loche S, et al. J Clin Endocrinol Metab. PMID: 9062497
This review summarizes evidence that the non-GHSR receptor CD36 acts as a specific cardiac receptor for hexarelin and mediates its cardioprotective effects.
Mao Y, et al. J Geriatr Cardiol. PMID: 25278975
This product is intended exclusively for in-vitro laboratory research. It is not a drug, food, dietary supplement, or cosmetic, and it is not intended for human or veterinary diagnostic, therapeutic, or recreational use.
