Description
Research Peptide≥99% HPLC StandardShips from Canada
Overview
Melanotan-1 (afamelanotide) is a synthetic linear analog of α-melanocyte-stimulating hormone (α-MSH), modified for stability. Unlike the broader-acting Melanotan-2, it is relatively selective for the MC1 receptor. It is supplied as a stable lyophilized peptide.
In research it is studied for pigmentation and photoprotection: MC1R activation on melanocytes drives production of the dark pigment eumelanin, which absorbs and scatters ultraviolet light. It is offered strictly as a research material, and the study cited below describes clinical-pharmacology findings only.
Mechanisms of interest in research
MC1 receptor agonism and eumelanin synthesis
Melanotan-1 activates the MC1 receptor on melanocytes, switching pigment production toward eumelanin. This melanogenic action is the central mechanism studied and underlies its interest in photoprotection research.
Photoprotection models
Because eumelanin absorbs ultraviolet radiation, increased eumelanin is examined for reduced phototoxicity, including in light-sensitivity conditions.
Specifications
Selected Research
The following peer-reviewed studies are provided for scientific context on this compound’s research background. They describe preclinical and in-vitro findings only and are not claims about this product.
In a randomized trial in patients with erythropoietic protoporphyria, afamelanotide increased pain-free sun-exposure time and reduced phototoxic reactions.
Langendonk JG, et al. N Engl J Med. PMID: 26132941
This product is intended exclusively for in-vitro laboratory research. It is not a drug, food, dietary supplement, or cosmetic, and it is not intended for human or veterinary diagnostic, therapeutic, or recreational use.
