Description
Research Peptide≥99% HPLC StandardShips from Canada
Overview
MOTS-c (mitochondrial ORF of the twelve-S rRNA type-c) is a 16-amino-acid peptide encoded within the mitochondrial genome rather than the nucleus. It is one of a small group of mitochondrial-derived peptides and is supplied as a stable lyophilized peptide.
In research it is studied as a mitochondrial signal that regulates whole-body metabolism, notably through activation of the energy sensor AMP-activated protein kinase (AMPK) and translocation to the nucleus under metabolic stress. It is offered strictly as a research material, and the study cited below describes preclinical findings only.
Mechanisms of interest in research
Folate cycle, purine biosynthesis and AMPK activation
MOTS-c has been shown to act on the folate cycle and its linked de-novo purine biosynthesis, raising AICAR and activating AMPK — the cellular energy sensor that shifts metabolism toward glucose uptake and fatty-acid oxidation.
Metabolic homeostasis and insulin sensitivity
Through AMPK signalling, MOTS-c is studied for effects on insulin sensitivity and protection against diet-induced metabolic dysfunction in animal models.
Nuclear translocation and stress-adaptive gene expression
Under metabolic stress MOTS-c can move to the nucleus and influence antioxidant and metabolic gene programs, a mechanism examined as a mitochondrial-to-nuclear signal.
Specifications
Selected Research
The following peer-reviewed studies are provided for scientific context on this compound’s research background. They describe preclinical and in-vitro findings only and are not claims about this product.
This study identified MOTS-c as a mitochondrial-derived peptide that inhibits the folate cycle and de-novo purine biosynthesis, activating AMPK and preventing insulin resistance and diet-induced obesity in mice.
Lee C, et al. Cell Metab. PMID: 25738459
In mice, regular moderate-intensity running raised hypothalamic MOTS-c expression and induced a mitochondrial unfolded-protein response and thermogenesis in adipose tissue.
Kang GM, et al. Cell Metab. PMID: 33535098
This product is intended exclusively for in-vitro laboratory research. It is not a drug, food, dietary supplement, or cosmetic, and it is not intended for human or veterinary diagnostic, therapeutic, or recreational use.
