Description
Research Compound≥99% HPLC StandardShips from Canada
Overview
NAD (nicotinamide adenine dinucleotide) is a dinucleotide coenzyme present in every living cell, existing in oxidised (NAD⁺) and reduced (NADH) forms. It is a small molecule rather than a peptide and is supplied here as a stable lyophilized compound.
In research NAD⁺ is studied both as a carrier of electrons in energy metabolism and as a consumable cosubstrate for enzymes such as the sirtuins, PARPs and CD38 that regulate metabolism, DNA repair and cellular ageing. It is offered strictly as a research material, and the study cited below describes review findings only.
Mechanisms of interest in research
Redox coenzyme in energy metabolism
As NAD⁺/NADH, the molecule shuttles electrons through glycolysis, the citric-acid cycle and oxidative phosphorylation. This central role in cellular energy production is the foundation of its biochemistry.
Cosubstrate for sirtuins and other NAD⁺-consuming enzymes
Beyond redox chemistry, NAD⁺ is consumed by sirtuins, PARPs and CD38. Its availability therefore sets the activity of these enzymes, linking NAD⁺ levels to metabolic regulation, DNA repair and stress responses in research models.
NAD⁺ metabolism and cellular ageing
Because cellular NAD⁺ declines with age, its salvage and supplementation are studied for effects on health span and metabolic function.
Specifications
Selected Research
The following peer-reviewed studies are provided for scientific context on this compound’s research background. They describe preclinical and in-vitro findings only and are not claims about this product.
This review summarizes evidence that NAD⁺ acts as a cosubstrate for sirtuins and other enzymes and that modulating NAD⁺ production or usage can influence health span and life span in model systems.
Verdin E. Science. PMID: 26785480
This product is intended exclusively for in-vitro laboratory research. It is not a drug, food, dietary supplement, or cosmetic, and it is not intended for human or veterinary diagnostic, therapeutic, or recreational use.
