Description
Research Peptide≥99% HPLC StandardShips from Canada
Overview
SS-31 (also known as elamipretide) is a synthetic, cell-permeable tetrapeptide (D-Arg-2′,6′-dimethyl-Tyr-Lys-Phe-NH₂) belonging to the Szeto–Schiller family of mitochondria-targeting peptides. Its aromatic-cationic structure lets it concentrate in the inner mitochondrial membrane. It is supplied as a stable lyophilized peptide.
In research it is studied for a single, well-defined action: binding the inner-membrane phospholipid cardiolipin to stabilise mitochondrial structure and improve energy production under stress. It is offered strictly as a research material, and the study cited below describes preclinical findings only.
Mechanisms of interest in research
Cardiolipin binding and cristae stability
SS-31 selectively associates with cardiolipin, a phospholipid unique to the inner mitochondrial membrane that organises the cristae folds housing the electron-transport chain. By stabilising cardiolipin the peptide is studied for preserving cristae architecture and the efficiency of ATP production.
Electron transport and reactive-oxygen-species control
By protecting the cardiolipin–respiratory-complex interaction, SS-31 is associated in models with improved electron-transport-chain function and reduced leakage of reactive oxygen species, linking it to research on oxidative stress.
Mitochondrial-stress and neuroinflammation models
These mitochondrial-protective effects are examined in models of metabolic, cardiac and neurological stress, where mitochondrial dysfunction is an underlying feature.
Specifications
Selected Research
The following peer-reviewed studies are provided for scientific context on this compound’s research background. They describe preclinical and in-vitro findings only and are not claims about this product.
In mice, SS-31 ameliorated LPS-induced learning and memory impairment while protecting against mitochondrial dysfunction, oxidative stress and neuroinflammation.
Zhao et al. J Neuroinflammation. PMID: 31747905
In a clinical trial, elamipretide improved the cardiolipin-to-monolysocardiolipin ratio — a direct measure of inner-membrane composition — in correlation with clinical outcomes.
Thompson WR, et al. Genet Med. PMID: 38602181
This product is intended exclusively for in-vitro laboratory research. It is not a drug, food, dietary supplement, or cosmetic, and it is not intended for human or veterinary diagnostic, therapeutic, or recreational use.
