Description
Research Peptide≥99% HPLC StandardShips from Canada
Overview
Tesamorelin is a synthetic analog of growth-hormone-releasing hormone (GHRH 1-44) stabilised by an N-terminal trans-3-hexenoyl group that resists enzymatic degradation. It is supplied as a stable lyophilized peptide.
As a GHRH-receptor agonist it is studied for its ability to stimulate endogenous, pulsatile GH release and the downstream IGF-1 response, and much of its literature concerns effects on visceral-adipose tissue and related metabolic endpoints. It is offered strictly as a research material, and the studies cited below describe preclinical and clinical-pharmacology findings only.
Mechanisms of interest in research
GHRH-receptor agonism
Tesamorelin activates the GHRH receptor on pituitary somatotrophs to promote synthesis and pulsatile release of endogenous GH, distinguishing it from direct GH administration by preserving the body’s own feedback control in model systems.
Visceral-adipose and metabolic endpoints
A defining research focus is the effect of restored GH signalling on visceral (central) adipose tissue; tesamorelin has been studied for reductions in central fat accumulation and for related changes in muscle and lipid endpoints.
Specifications
Selected Research
The following peer-reviewed studies are provided for scientific context on this compound’s research background. They describe preclinical and in-vitro findings only and are not claims about this product.
This review reports that tesamorelin, a GHRH analog, was safe and effective at reducing central fat accumulation in HIV-infected patients in randomized trials, though the effect was transient.
Bedimo R. HIV AIDS (Auckl). PMID: 22096409
In a randomized-trial secondary analysis, tesamorelin increased trunk skeletal-muscle density and area compared with placebo over 26 weeks.
Adrian S, et al. J Frailty Aging. PMID: 31237318
This product is intended exclusively for in-vitro laboratory research. It is not a drug, food, dietary supplement, or cosmetic, and it is not intended for human or veterinary diagnostic, therapeutic, or recreational use.
